Endocrine Abstracts

Background: Primary aldosteronism (PA) has been reported to affect about 10% of patients with essential hypertension. In Western countries, about one third of them have aldosterone-producing adenomas (APA), and mutations of the KCNJ5 gene have recently been identified in approximately 30% of APAs. In contrast, most Japanese (~80%) with PA have APA. Therefore, Japanese PA may have different characteristics from patients in Western countries, and those with mutations of the KCNJ...